Latest technologies from

SoftSCREEN – A Shape-shifting Capsule Robot for GI Endoscopy

s.anastassiou@uclb.com — Wed, 16 Sep 2020 05:51:13 GMT

Available For: Licensing

Summary

{{start}} Soft Shape-shifting Capsule Robot for Endoscopy based on Eversion Navigation (SoftSCREEN). A novel design for a capsule robotic system that propels itself through the gastrointestinal (GI) tract by means of a series of continuously everting elastic tracks (i.e. the tracks go from the inside of the capsule to the outside in a continuous manner) distributed all around its body. {{end}}

The Technology and its Advantages

A proof-of-concept tethered SoftSCREEN system for colon screening is shown in Fig. 1. The ma...

Pneumatically Attachable Flexible (PAF) Rails for Laparoscopic Surgery

s.anastassiou@uclb.com — Tue, 23 Jun 2020 04:04:52 GMT

Available For: Licensing

Summary

{{start}} A novel multi-purpose surgical technology for intra-operative organ imaging and safe organ manipulation. {{end}}

The Technology and its Advantages

Robotic-assisted partial nephrectomy (RAPN) is the second most common robotic-assisted surgical procedure. Performed laparoscopically, ie. via keyhole surgery, a portion of a kidney is removed to prevent the spreading of the tumour to healthy tissue. To define the margins for resection intra-operative ultrasound (US) scanning is performed using small probes passed throu...

Dry Eye Diagnosis and Monitoring Software

s.anastassiou@uclb.com — Wed, 25 Mar 2020 05:37:26 GMT

Available For: Exclusive/Non-Exclusive/Option

Summary

{{start}} Clinicians at Moorfields Eye Hospital, the leading provider of eye health services in Europe have developed software which is able to quantify dry eye in a patient. The software quantifies the number, distribution and size of fluorescein staining allowing screening, diagnosis and monitoring of the dry eye and other eye diseases. {{end}}

The Technology and its Advantages

{{start}} Corneal staining with fluorescein is used to diagnose and manage common eye problems from dry eyes and allergic eye...

Neidle_Quadruplex-binding compounds - A novel anticancer strategy

s.anastassiou@uclb.com — Thu, 21 Nov 2019 03:14:48 GMT

Available For: Exclusive Licensing

Summary

{{start}} We have a first-in-class optimized small-molecule drug candidate ready for IND enabling studies with superior efficacy and activity against pancreatic cancer compared to existing agents, together with a distinct mechanism of action.{{end}}

The Technology and its Advantages

The development of a malignancy within the pancreas is a multistep process, several key oncogenes must be activated and tumor suppressor genes inactivated in order for cells to proliferate indiscriminately. We have developed a lead com...

Collagen for tendon repair

s.anastassiou@uclb.com — Fri, 15 Nov 2019 06:21:28 GMT

Available For: Exclusive Licensing/Non-exclusive Licensing

Summary

{{start}}Collagen is the most widely distributed class of proteins in the human body and the use of collagen-based biomaterials in the field of tissue engineering is extensive. However collagen hydrogels typically have low mechanical strength, and accordingly may not be suitable for use in tendon and other tissue repair grafts without further processing. Whilst there are methods available to increase the strength of collagen, they are not suitable for fabrication of certain tissues as the shape of...

Synthetic engineered potassium channel (EKC) for gene therapy

s.anastassiou@uclb.com — Tue, 20 Jun 2017 07:42:23 GMT

Available For: Licensing

Summary

{{start}} Epilepsy affects around 60 million people globally and there remains an urgent need for novel treatment methods. Researchers at UCL Institute of Neurology have developed a novel synthetic engineered potassium channel (EKC) as a gene therapy tool to treat epilepsy and other neurological conditions. The inventors have preclinical results demonstrating their engineered potassium channel reduces seizures in a rodent model of epilepsy. {{end}}

The Technology and its Advantages

It is estimated that, of the 60 mil...

Tau-gene-specific non-coding RNA genes for the therapeutic reduction of tau levels

s.anastassiou@uclb.com — Fri, 02 Jun 2017 08:19:02 GMT

Available for: Exclusive/Non-Exclusive licensing

Summary

{{start}} During genome transcription, both coding and non-coding transcripts are generated with a wide range of both size and coding potential. Among these are long non-coding RNA (lncRNA) genome transcripts, some of which are antisense to protein-coding genes (AS-lncRNAs). These AS-lncRNAs have been shown to regulate chromatin state, transcription, RNA stability, and translation of the gene. Researchers at UCL have developed a therapeutic RNA molecule that corresponds with an AS-lncRNA, which can modulate the express...

LipoGlucoCEST - Novel Imaging Agents for GlucoCEST

s.anastassiou@uclb.com — Tue, 09 May 2017 07:58:20 GMT

Available For: Licensing

Summary

{{start}} GlucoCEST is a magnetic resonance imaging (MRI) technique that enables visualisation of natural, non-radioactive glucose that can be used in cancer diagnosis. However, this technique has limitations due to interactions with the body glucose sensing system. To solve this problem, researchers at UCL Institute of Neurology and Department of Chemistry have developed a novel set of imaging agents based on liposome-encapsulated sugar compounds that addresses these issues. {{end}}

The Technology and its Advantages

Chemi...

Vander Poorten: Device and method for force measurement in simulated minimal invasive surgery

s.anastassiou@uclb.com — Tue, 09 May 2017 02:12:58 GMT

Available For: Licensing

Summary

{{start}} A training device for minimally invasive surgery with built-in force sensing. {{end}}

The Technology and its Advantages

The demand for ‘minimally invasive’, ‘laparoscopic’ or ‘key-hole’ surgery techniques has increased in recent years driven by factors such as increasing healthcare costs, rising focus on patient safety and the availability of new technologies. Whilst the demand has increased, the adoption of these types of techniques by healthcare professionals has been inhibit...

New lentiviral platform eliminating packaging sequences from the transcribed DNA region

s.anastassiou@uclb.com — Fri, 27 Mar 2015 03:34:52 GMT

Available for: Exclusive/Non-exclusive Licensing

Summary

{{start}} All lentiviral vectors described to date contain packaging sequences necessary for the viral RNA genome to be assembled into viral particles. These sequences are unnecessarily reverse transcribed into DNA and permanently integrate into target cells. The researchers at UCL Institute of Child Health have developed a lentiviral platform which does not reverse transcribe the packaging sequences into the target cells. {{end}}

The Technology and its Advantages

In all existing lentiviral vectors, ...

Drug Delivery System for Crossing the Blood Brain or Blood Retinal Barrier (UDDS)

s.anastassiou@uclb.com — Wed, 25 Mar 2015 04:50:23 GMT

Available For: Exclusive licensing

Summary

{{start}} The blood retinal barrier (BRB), and the blood brain barrier (BBB), represent a significant impediment to drug delivery to the eye and the brain, respectively. This lack of drug penetration has resulted in diseases, such as Age-related Macular Degeneration (AMD), Alzheimer's Disease and Stroke being extremely difficult to address.Although therapies to eye disease such as AMD already exist, they are delivered by intraocular injections with high risk of side effects related to the administration, the most significant being r...

Passive Wireless Detection System

s.anastassiou@uclb.com — Tue, 16 Dec 2014 08:21:48 GMT

Available for: Licensing and Joint Development

Summary

{{start}} A team of researchers at UCL's Department of Electronic and Electrical Engineering, have developed a method for detection and tracking using existing wireless signals (WiFi) present in the everyday environment. {{end}}

The Technology and its advantages

The Passive Wireless Detection System uses software defined radio architecture, which includes proprietary signal processing and a graphic user interface. The hardware consists of a reference antennas and a surveillance antenna, the c...

III-V laser diodes on germanium substrates

s.anastassiou@uclb.com — Fri, 25 Jul 2014 04:24:55 GMT

Available For: Licensing and joint development

Summary

{{start}} The Photonics Research Group at UCL have recently developed and demonstrated a monolithically integrated III-V compound semiconductor photonic structure on a Silicon substrate. The monolithic III-V on Silicon device opens up new possibilities for integrated system-on-a-chip designs with high bandwidth and high data transfer rates. {{end}}

The Technology and Its Advantages

The desire to achieve ever-greater performance from electronic devices and circuitry is driving the development of faster ...

Formulations for the Prevention of Neural Tube Defects

s.anastassiou@uclb.com — Mon, 26 Nov 2012 04:05:11 GMT

Available for: License

Summary

{{start}} Exploring ways to prevent birth defects, researchers at the UCL Institute of Child Health have discovered novel supplements that if taken in pregnancy can reduce the chance of the baby having neural tube defects such as spina bifida or anencephaly. These are important in pregnancies where folic acid and other supplements are not as effective. A new patent has been filed we are supporting work to validate and test combinations in animal models. {{end}}

Market Opportunity

Maternal folic acid sup...

Compliment Factor H Related 5 protein (CFHR5) and kidney disease

s.anastassiou@uclb.com — Fri, 27 Jan 2012 04:12:08 GMT

Available for: Partnering, collaborative research ad licensing

Summary

{{start}}We have demonstrated that an abnormality of the protein Complement Factor H Related 5 (CFHR5) leads to a disposition of complement C3 and kidney failure. we have invented an efficient test for this genetic abnormality and have used it to screen a population. We have also invented an ELISA assay to measure the circulating CFHR5 protein levels in humans. We believe this will be useful in diagnosis and assessment of patients with a variety of diseases including SLE, immune complex glomerul...

Magnetic Microbubbles

s.anastassiou@uclb.com — Tue, 01 Mar 2011 03:50:04 GMT

Available For: Licensing and collaborative development

Summary

{{start}} Magnetic microbubbles can be injected into the blood stream and may be directed to a specific body location by the application of an external magnetic field. They enhance ultrasound images, and can be used to deliver, and promote uptake of, cargo molecules such as drugs, antibodies or DNA. They thus have many potential applications in clinical settings, as well as in both basic and medical research. {{end}}

The Technology and its Advantages

Microbubbles are tiny bubbles of gas (1-10&m...

Ultra-Fast Fluidic Analysis

s.anastassiou@uclb.com — Tue, 01 Mar 2011 03:49:57 GMT

Available For: Licensing and collaborative development

Summary

{{start}} A research group at UCL have developed a new microfluidic-based method which can be used in combination with either chemical or optical heating-based denaturation to measure protein stability curves and calculate affinity constants from nanolitre sample volumes. Measurement times are significantly reduced from standard methods and envisaged applications range from high-throughput drug discovery to healthcare diagnostics and pathogen detection. {{end}}

The Technology and its Advantages

Dengue Virus High-Throughput Fluorescent Assay

s.anastassiou@uclb.com — Tue, 01 Mar 2011 03:49:51 GMT
Available For: Non-exclusive licenses.
Summary
{{start}}We have developed a novel fluorescent assay for the screening of small molecules targeting dengue virus.{{end}}
The Technology and its Advantages
Our technology is based on stable cell lines expressing a replicon of dengue virus, optimised for assessing drug efficacy in vitro through incorporation of a fluorescent reporter element.
Market opportunity
Dengue hemorrhagic fever is a flavivirus with the major disease burden occurring in South East Asia, the Americas and the Western Paci...

SnakeGrid (Local Coordinate Mapping)

s.anastassiou@uclb.com — Tue, 01 Mar 2011 03:49:35 GMT
Available For: Licensing and collaborative development
Summary
{{start}} SnakeGrid® products provide innovative solution to a significant problem in engineering surveying, namely the design of a coordinate system that has minimal scale factor and height distortion even when projects extend for many hundreds of kilometres. {{end}}
The Technology and its Advantages
SnakeGrid®, a registered trademark of UCL Business PLC, includes a range of bespoke and over the counter surveying solutions based on technologies developed in UCL Civil, En...

Voltage-Gated Sodium Channel Knockout Mice: Tools for Developing Therapeutics for the Treatment of Pain

s.anastassiou@uclb.com — Tue, 01 Mar 2011 03:49:26 GMT
Available for: Non-exclusive licensing
Summary
{{start}} Scientists at University College London have developed Voltage-Gated Sodium Channel subtype specific conditional knockout mice which provide invaluable tools for the development of therapeutics for the treatment of pain. {{end}}
The Technology and its Advantages
University College London have developed the following subtype specific knockout mice:-"NaV1.3 flox"-Transgenic mouse expressing floxed NaV1.3 sodium channel gene-"NaV1.7 flox"-Transgenic mouse expressing floxed NaV1.7 sod...

New Micro-Cantilever Configuration

s.anastassiou@uclb.com — Tue, 01 Mar 2011 03:49:17 GMT
Available for: Licensing and collaborative development
Summary
{{start}} A team at London Centre for Nanotechnology are developing a device that is already being used to detect the presence viruses, bacteria and proteins from a single sample. It is based on a cantilever sensing method and is configured to give binding energy information as well as a quantative assay. The new system has already displaced use of the commercially available system in the Lab as the virologists find the new configuration much easier to use. The project is currently supported by the EPSRC for res...

Bioactive Coating

s.anastassiou@uclb.com — Tue, 01 Mar 2011 03:49:00 GMT
Available for: Licensing
Summary
{{start}}A novel method of creating an inter-locked (high bond strength) bioactive coating on metallic substrates for orthopaedic applications.{{end}}
The Technology and its Advantages
The lack of methodology for producing strongly-bonded bioactive coatings on metallic alloys is an impediment to the development of economical and robust orthopaedic technologies, such as those encountered in hip replacement. Current practice is dependent on generating an expensive plasma-sprayed coating of a bioactive substance o...

Self-Disinfecting Computer Keyboard

s.anastassiou@uclb.com — Tue, 01 Mar 2011 03:48:43 GMT
Available for: Licensing
Summary
{{start}} Ambient lighting conditions activate a proprietary keyboard surface resulting in disinfection. These keyboards can be used in healthcare facilities to help prevent the spread of healthcare acquired infections (HCAIs). {{end}}
The Technology and Its Advantages
Light-activated antimicrobial agents (LAAs) are compounds which, when irradiated with light of an appropriate wave length, produce singlet oxygen which kill microbes. Academics at UCL have incorporated LAAs into common keyboard plastics and have demonstrated ...

SnakeGrid Transformer for CAD

s.anastassiou@uclb.com — Tue, 01 Mar 2011 03:48:41 GMT
Available For: Licensing and collaborative development
Summary
{{start}} Based on research at UCL Civil, Environmental and Geomatic Engineering Department, SnakeGrid® Transformer is a plug-in software module for the Bentley MicroStation CAD package and allows the conversion of Bentley MicroStation design files "on the fly" between different SnakeGrids®, London Survey Grid, British National Grid settings and local grids such as the Reading Grid. {{end}}
The Technology and its Advantages
SnakeGrid® Transformer has been developed ke...