Search Results - Therapeutic

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Tau-gene-specific non-coding RNA genes for the therapeutic reduction of tau levels
Available for: Exclusive/Non-Exclusive licensing<h2>Summary</h2>{{start}} During genome transcription, both coding and non-coding transcripts are generated with a wide range of both size and coding potential. Among these are long non-coding RNA (lncRNA) genome transcripts, some of which are antisense to protein-coding genes (AS-lncRNAs)...
Published: 02/06/2017   |   Inventor(s): Rohan de Silva, Roberto Simone
Keywords(s): Central Nervous System (CNS)
Category(s): Therapeutic
Lrg-1 antagonists: Direct effect upon cancer cells
Available for: Exclusive/Non-exclusive licensing<h2>Summary</h2>{{start}} The formation of new blood vessels by angiogenesis is a key feature of number of diseases including Age-related Macular Degeneration (AMD), Proliferative Diabetic Retinopathy (PDR), atherosclerosis, rheumatoid arthritis and cancer. Vascular Endothelial Growth Fact...
Published: 29/10/2015   |   Inventor(s): Stephen Moss, Xiaomeng Wang, John Greenwood
Keywords(s): Cancer, Ophthalmology & Optometry
Category(s): Antibodies & Binding Agents, Therapeutic
Novel Therapy for Polycystic Kidney Disease (PKD)
Available for: Exclusive/Non-Exclusive Licensing<h2>Summary</h2>{{start}} Polycystic kidney disease is the most common inherited cause of kidney failure, affecting 1 in 1000 adults and children worldwide. It is characterized by the growth of multiple cysts leading to loss of normal kidney structure and functions and often results in end...
Published: 18/03/2015   |   Inventor(s): Paul Winyard, David Andrew Long, Jennifer Huang
Keywords(s): Kidneys & Genitourinary System
Category(s): Delivery of Drugs/Molecules, Gene/Cell Therapy, Therapeutic
Treatment of fibrosis with ALDH inhibitors
Available for: Exclusive Licensing<h2>Summary</h2>{{start}} Fibrosis is the formation of excess fibrous connective tissue in response to injury and inflammation. If it happens in response to injury it is also referred to as scarring. Fibrosis is associated with conditions such as cystic fibrosis, cirrhosis, mucous membrane pemphigoid (M...
Published: 13/03/2015   |   Inventor(s): Virginia Calder, David Abraham, Sarah Dale
Keywords(s): Ophthalmology & Optometry
Category(s): Therapeutic
H4R antagonists for uveitis and other inflammatory diseases
Available For: Exclusive Licensing<h2>Summary</h2>{{start}} Histamine is a pleiotropic mediator involved in a variety of physiological processes including neurotransmission, endocrine and vascular processes. It also plays a key role in inflammation and binding to one of its four receptors (H1R-H4R). Researchers at UCL Institute of Opht...
Published: 12/03/2015   |   Inventor(s): Virginia Calder, Spyridon Chalkiadakis
Keywords(s): Ophthalmology & Optometry
Category(s): Therapeutic
Imatinib and other ABL inhibitors to treat ocular neovascularisation
Available for: Exclusive Licensing<h2>Summary</h2>{{start}} Retinal and choroidal diseases are the most common cause of vision loss in the western world. They are either caused by the leakage and neovasculatisation from retinal vessels (diabetic retinopathy, retinal vein occlusions, retinopathy of prematurity and neovascular glaucoma) o...
Published: 12/03/2015   |   Inventor(s): Christina Rhurberg
Keywords(s): Ophthalmology & Optometry
Category(s): Therapeutic
Formulations for the Prevention of Neural Tube Defects
Available for: License<h2>Summary</h2>{{start}} Exploring ways to prevent birth defects, researchers at the UCL Institute of Child Health have discovered novel supplements that if taken in pregnancy can reduce the chance of the baby having neural tube defects such as spina bifida or anencephaly. These are important in pregnancies where ...
Published: 26/11/2012   |   Inventor(s): Nicholas Greene, Andrew Copp
Keywords(s): Women's Health & Obstetrics
Category(s): Therapeutic
Agonists at the Natriuretic Peptide Receptor-C with Therapeutic Potential for Cardiovascular Disease
Available for: Licensing and co-development<h2>Summary</h2>{{start}}Scientists at UCL have developed small molecule CNP mimetics selective for NPR-C, which they have identified as a druggable target for a group of cardiovascular diseases.{{end}}<h2>The Technology and its Advantages</h2>C-type natriuretic peptide (CNP) belong...
Published: 01/03/2011   |   Inventor(s): Adrian Hobbs, David Selwood, Amrita Ahluwalia
Keywords(s): Cardiovascular & Circulatory System
Category(s): Therapeutic
Magnetic Hyperthermia Device for Healthcare and Industrial Applications
Available for: Licensing<h2>Summary</h2>{{start}} Exposure of magnetic nanoparticles to an alternating magnetic field results in localised heating which can kill cells in the immediate vicinity of the heated nanoparticles. This device may be useful for antimicrobial and cancer treatment or for numerous industrial applications. {{end}}&l...
Published: 01/03/2011   |   Inventor(s): Quentin Pankhurst, Paul Southern, Simon Hattersley
Keywords(s): Cancer, Healthcare & Research Services
Category(s): Medical Devices, Therapeutic
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